Neonatal bacilllus Calmette-Guerin (BCG) administration did not limit influenza A virus replication or clinical disease in pigs

نویسندگان

چکیده

Abstract A potential immunomodulation mechanism for improving disease resilience is innate training, which relies on epigenetic modifications of immune cells a heightened (ie, trained) response upon repeated microbial stimulation. Prior experiences indicate bacillus Calmette-Guerin (BCG) exposure increases cytokine production secondary to microbe-associated molecular patterns, and epidemiological data suggest improved resistance in humans administered neonatal BCG. Neonatal piglets received BCG or mock inoculum via intravenous (IV) route were subsequently exposed influenza virus (IAV) inoculated piglets. Body temperature was recorded nasal swabs collected through the acute phase viral infection. At necropsy, gross lung pathology assessed. In addition, prior IAV challenge, peripheral blood mononuclear (PBMC) monocytes isolated from animals stimulated vitrowith LPS evaluate vivoinduction trained phenotype gene expression. PBMC with PPD antigen assess antigen-specific T cell responses inoculation. PPD-specific IFNγ by PBMCs minimal; yet vitroLPS exposure, IV treated produced more IL-1β TNF than pigs phenotype). However, no significant differences clinical presentation titers detected. administration induced porcine monocytes, it did not translate into alteration respiratory USDA-ARS-NIFA 2019-07511

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ژورنال

عنوان ژورنال: Journal of Immunology

سال: 2023

ISSN: ['1550-6606', '0022-1767']

DOI: https://doi.org/10.4049/jimmunol.210.supp.73.09